HPMC/Hydroxypropyl Methylcellulose

HPMC/Hydroxypropyl Methylcellulose

Hypromellose (INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used as eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.

Introduction

Hypromellose (INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used as eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products. As a food additive, hypromellose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin. Its Codex Alimentarius code (E number) is E464.


Functions and Applications

1.Use in whole grain breads: Agricultural Research Service scientists are investigating using the plant-derived HPMC as a substitute for gluten in making all-oat and other grain breads. Gluten, which is present in wheat, rye, and barley is absent (or present only in trace quantities) in oat and other grains. Like gluten, HPMC can trap air bubbles formed by the yeast in bread dough, causing the bread to rise.

2.Use in construction materials:HPMC is used primarily in construction materials like tile adhesives and renders where it is used as a rheology modifier and water retention agent. Functionally HPMC is very similar to HEMC (hydroxy ethyl methyl cellulose) Trade names include Methocel and Walocel. The global leading producer is Dow Wolff Cellulosics GmbH.

3.Excipient/tableting ingredient: In addition to its use in ophthalmic liquids, hypromellose has been used as an excipient in oral tablet and capsule formulations, where, depending on the grade, it functions as controlled release agent to delay the release of a medicinal compound into the digestive tract. It is also used as a binder and as a component of tablet coatings. 

      Grade             ValueLtems  HPMC
65GSK60GSK75GSK
Hydroxypropoxyl:wt%4.0-7.57.0-12.0 4.0-12.0
Methoxyl content:wt%27.0-30.028.0-30.019.0-24.0
Gelation temperature℃62-6858-6470-90
Ash ciontennt:wt%Not more than 1.0
Moisture:wt%Not more than 5.0
viscosity(2wt%solution)3-100000
PH value(1wt%solution)4-8
Chlorides:(NaCl)wt%Not more than 0.2
Arsenic:ppmNot more than 2
Heavy metals:ppmNot more than 20

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