Pancreatin CAS 8049-47-6

Pancreatin CAS 8049-47-6

Pancreatic enzymes also known as pancrelipase and pancreatin, are commercial mixtures of amylase, lipase, and protease. They are used to treat malabsorption syndrome due to pancreatic problems. These pancreatic problems may be due to cystic fibrosis, surgical removal of the pancreas, long term pancreatitis, or pancreatic cancer among others.

Introduction

Pancreatic enzymes also known as pancrelipase and pancreatin, are commercial mixtures of amylase, lipase, and protease. They are used to treat malabsorption syndrome due to pancreatic problems. These pancreatic problems may be due to cystic fibrosis, surgical removal of the pancreas, long term pancreatitis, or pancreatic cancer among others. It is taken by mouth. Common side effects include vomiting, abdominal pain, constipation, and diarrhea. Other side effects include perianal irritation and high blood uric acid. The enzymes are from pigs. Use is believed to be safe during pregnancy. The components are digestive enzymes similar to those normally produced by the human pancreas. They help the person digest fats, starches, and proteins. Pancreatic enzymes have been used as medications since at least the 1800s. They are on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. In the United Kingdom a typical month supply costs the NHS about 11.64 pounds. In the United States a month of treatment typically costs 50 to 100 USD.

Functions and Applications

Used in medical: Pancrelipases are generally a first line approach in treatment of exocrine pancreatic insufficiency and other digestive disorders, accompanying cystic fibrosis, complicating surgical pancreatectomy, or resulting from chronic pancreatitis. The formulations are generally hard capsules filled with gastro-resistant granules. Pancrelipases and pancreatins are similar, except pancrelipases has an increased lipase component.

Pancreatin Basic information
Product Name:Pancreatin
Synonyms:pancrex-v;pankreon;pankrotanon;panteric;viobin;viokase;Pancreatin NB from porcine pancreas;Pancreatin NB GMP Grade from porcine pancreas
CAS:8049-47-6
MF:N/A
MW:0
EINECS:232-468-9
Product Categories:Enzyme;Inhibitors
Mol File:Mol File
 Application Mainly used in the leather industry, enzymatic hair removal, also used in the textile printing and dyeing industry
Used in biochemical research, clinically used as a digestive drug for digestive disorders, loss of appetite, digestive disorders caused by pancreatic diseases, and dyspepsia in diabetic patients.
Pancreatin Chemical Properties
storage temp. −20°C
solubility Soluble or partly soluble in water forming a slightly turbid solution; practically insoluble in ethanol (96%) and in ether .
form powder
color beige
Water Solubility Soluble in water. Insoluble in alcohol and ether.
Merck 137,075
Stability:Stable. Incompatible with alcohols, strong acids.
EPA Substance Registry SystemPancreatin(8049-47-6)






 

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