Bone Support · Energy Boost · Anti-Aging Innovation Fermentation-Based | Clean Label | High Purity | In-Stock Ideal for Gummies, Tablets, Capsules, Anti-Aging & Sports
Introduction
Advantages of Biological Fermentation:
Core Differences Between Chemical Synthesis and Bio Fermentation of AKG/Ca-AKG
Biofermentation | Chemical Synthesis | |
Raw Materials | ✅Renewable sources | ❌ Glutaric acid |
Reaction Conditions | ✅ Mild conditions | ❌ High temperature & pressure |
Environmental Impact | ✅ Green process | ❌ High pollution |
Yield & Purity | ✅ High yield | ❌ Low yield |
Equlpment Investment | ✅ Lower cost | ❌ High-cost |
Production Time | ✅ 24-72h fermentation cycle | ❌ Slow purifcation |
Functions and Applications
What is Ca-AKG?
①Chemical structure and nomenclature：
Chemical formula is Ca(C₅H₅O₅)₂, which is the divalent calcium salt of α-Ketoglutarate.
Features: α-Ketoglutarate is a five-carbon dicarboxylic acid (HOOC-C(=O)-CH₂-CH₂-COOH), containing one ketone group (C=O) and two carboxyl groups (-COOH). The calcium salt form is obtained by the deprotonation of the carboxyl groups followed by binding with Ca²⁺.
② Physical property：
Appearance: White or off-white crystalline powder.
Solubility: It is slightly soluble in water (the solubility of calcium salts is generally lower than that of sodium or potassium salts), and its solubility may increase in acidic environments.
Stability: It is relatively stable to light and heat, but may decompose under strong acidic or alkaline conditions.
③ Chemical property：
Acidity/Alkalinity: As a carboxylate, its aqueous solution exhibits weak alkalinity (pH 7-9).
Reactivity:
Decarboxylation: It may undergo decarboxylation to form succinic acid or carbon dioxide under high temperature or enzymatic catalysis.
Complexing ability: α-Ketoglutarate is a metal chelator and may bind with other metal ions.
Antioxidant property: It indirectly exerts antioxidant effects by scavenging free radicals or participating in the glutathione cycle.
④ Biochemical property：
Tricarboxylic acid cycle (TCA cycle): α-Ketoglutarate is a core intermediate of the TCA cycle, participating in energy metabolism (ATP production) and amino acid synthesis (such as glutamate and glutamine).
Calcium supplementation: Provides biologically available calcium ions, which may support bone health.
Signal regulation: In cells, it participates in regulating the stability of hypoxia-inducible factor (HIF), affecting gene expression and cellular metabolic adaptation.
Why Calcium AKG/Ca-AKG?
① Anti Aging Benefits – Promotes longevity by supporting mitochondrial function
and reducing oxidative stress
②Dual Action Formula – Provides essential calcium+ AKG to support bone strength and cellular health
③Clean Label Ingredient – Produced via fermentation, free from synthetic additives
④ Third-Party Tested – Verified quality and consistency
Microbial Test(s)
Code | Test ltem(s) | Unit(s) | Test Method(s) | Test Result(s) |
5 | Coliforms | CFU/g | FDA/BAM online Chapter 4 | <10 |
6 | *Total Plate Count | CFU/g | AOAC 966.23 | <10 |
7 | *Total Combined Moldsand Yeasts Count | CFU/g | USP-NF <2021>,officialdate: Official as of 01-Aug2013 | <10 |
8 | *Salmonella | /10 g | USP-NF <2022>,officialdate: Official as of 01.Nov-2019 | ND |
9 | Staphylococcus aureus | /10 g | USP-NF<2022>,officialdate: Official as of 01-Nov-2019 | ND |
Chemical Test(s)
Code | Test ltem(s) | Unit(s) | Test Method(s) | Test Result(s) | LOQ |
10 | Purity of Calcium | % | Q/HHSW 2403S-2024 | 99.6 | - |
alpha-ketoglutarate | |||||
Monohydrate / a- | |||||
11 | Total Fat(as TG) | g/100 g | AOAC 996.06 | 0.0129 | 0.01 |
12 | Moisture | % | AOAC 925.10 | 0.53 | |
13 | pH Value | - | ChP 2020 Volume IV | 7.33 | - |
General Rule 0631 | |||||
14 | Protein | % | Refer to AOAC 930.29 | 0.31 | - |
15 | Loss On Drying | % | ChP 2020 Volume IV General Rule 0831 | <0.1 | - |
16 | Sodium(Na) | mg/kg | EN 16943:2017 | 303 | 10 |
17 | Potassium(K) | mg/kg | EN 16943:2017 | ND | 30 |
18 | lron(Fe) | mg/kg | EN 16943:2017 | ND | 3 |
19 | Lead (Pb) | mg/kg | USP<233>elemental impurities-procedures procedure 2USP<233> | 0.243 | 0.05 |
20 | Cadmium(Cd) | mg/kg | USP<233>elemental impurties-procedures procedure 2USP<233> | ND | 0.005 |
21 | Arsenic(As) | mg/kg | USP<233>elemental impurities-procedures procedure 2USP<233> | ND | 0.005 |
22 | Mercury (Hg) | mg/kg | USP<233>elemental impurities-procedures procedure 2USP<233> | ND | 0.003 |
23 | Calcium ion content | % | Q/HHSW 2403S-2024 | 19.9 | - |
24 | Crude ash | % | AOAC 923.03 | 49.1 | - |
Q&A
Q:Does the company accept sample orders?
A:Yes, our company accepts sample orders.
Q:What is the minimum order quantity for the company?
A:We do not have a minimum order quantity requirement, we arrange according to the customer's needs.
Q:How to ensure the quality of goods?
A:We have a strict QC/QA management system and strict release procedures, and we will provide all procedures to customers before shipment according to their requirements.
Q:Can we see the product quality before the order is shipped?
A:Of course, we always provide a relative Batach (s) 'COA before shipping.
Q:How will you deliver the goods?
A:We will communicate with customers, adopt their suggestions, arrange the most suitable delivery method, and ensure mutual satisfaction.
Inquiry
Add: Block 14, No.100, Luyun Road,Changsha 410205,China.
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